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Chromosomal Instability in Cancer Cells

Chromosomal Instability in Cancer Cells


Recent Results in Cancer Research, Band 200

von: B. Michael Ghadimi, Thomas Ried

CHF 59.00

Verlag: Springer
Format: PDF
Veröffentl.: 16.09.2015
ISBN/EAN: 9783319202914
Sprache: englisch

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Beschreibungen

Titelbeschreibung

<p>This issue of <i>Recent Results in Cancer Research</i> presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.</p>

Inhaltsverzeichnis

<p>DNA Repair and Chromosomal Translocations.- CINcere modelling: <i>What have mouse models for chromosome instability taught us</i>?.- Telomere Dysfunction, Chromosomal Instability and Cancer.- Genetic Instability and Disease Prognostication.- Causes of Chromosomal Instability.- Patterns of Chromosomal Aberrations in Solid Tumors.- Yeast as Models of Mitotic Fidelity.- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development.- Consequences of aneuploidy in cancer: transcriptome and beyond.</p>

Back cover copy

<p>This issue of <i>Recent Results in Cancer Research</i> presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.</p>

Sonderbeitrag

Reviews up-to-date knowledge of chromosomal instability in cancer Examines strategies to harness this information for the better treatment of cancer patients Written by acknowledged experts in the field Includes supplementary material: sn.pub/extras

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