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<p>List of Contributors XVII</p> <p>Preface XXV</p> <p><b>Part I Analytical Methods and Strategies in Metallomics 1</b></p> <p><b>1 The Position of Metallomics Within Other Omics Fields 3</b><br /><i>Dirk Schaumlöffel</i></p> <p>1.1 Introduction 3</p> <p>1.2 Metallome and Metallomics in Relation to Other “-Ome” and “-Omics” Fields 3</p> <p>1.3 Is Metallomics Feasible as a Global Study of the Metallome 7</p> <p>1.4 Approaching the Metallome: Study of Metallome Subgroups 8</p> <p>1.5 Analytical Strategies in Metallomics 8</p> <p>1.6 Functional Connections Between DNA, Proteins, Metabolites, and Metals 10</p> <p>1.7 Metallothiolomics as Example for Metallomics Studies of a Metallome Subgroup 11</p> <p>1.8 Concluding Remarks 14</p> <p>References 15</p> <p><b>2 Coupling Techniques and Orthogonal Combination of Mass Spectrometric Techniques 17</b><br /><i>Daniel Pröfrock</i></p> <p>2.1 Introduction 17</p> <p>2.2 Analytical Techniques for Metallomics 19</p> <p>2.3 Ionization Principles and Mass Spectrometric Detectors for Speciation 30</p> <p>2.4 Overview about Coupling Techniques 48</p> <p>2.5 Final Remarks and Outlook 58</p> <p>References 58</p> <p><b>3 Quality Control in Speciation Analysis Using HPLC with ICP-MS and ESI MS/MS: Focus on Quantitation Strategies Using Isotope Dilution Analysis 69</b><br /><i>Heidi G. Infante</i></p> <p>3.1 Introduction 69</p> <p>3.2 Synergetic Use of Elemental and Organic Mass Spectrometry in Compound Quantitation and Quality Assurance of Food Selenium Speciation 70</p> <p>3.3 The Role of Species-Specific Isotope Dilution in Increasing Metrological Traceability for the Quantification of Bioinorganic Species 72</p> <p>References 81</p> <p><b>4 Novel Methods for Bioimaging Including LA-ICP-MS, NanoSIMS, TEM/X-EDS, and SXRF 83</b><br /><i>Dirk Schaumlöffel, Robert Hutchinson, Julien Malherbe, Philippe Le Coustumer, Etienne Gontier, and Marie-Pierre Isaure</i></p> <p>4.1 Introduction 83</p> <p>4.2 Bioimaging by LA-ICP-MS 84</p> <p>4.3 Bioimaging by NanoSIMS 90</p> <p>4.4 Bioimaging by TEM/X-EDS 93</p> <p>4.5 Bioimaging by SXRF 104</p> <p>4.6 Conclusions and Outlook 108</p> <p>References 109</p> <p><b>5 Electrochemistry Coupled toMass Spectrometry for Investigating Oxidative Metabolism of Pt-Based Drug Conjugates: A Novel Approach 117</b><br /><i>Günther Weber</i></p> <p>5.1 Introduction 117</p> <p>5.2 EC-MS Methodology 119</p> <p>5.3 EC-MS of Thiols 119</p> <p>5.4 Influence of Cisplatin on Thiol Oxidation 121</p> <p>5.5 Conclusions 125</p> <p>References 126</p> <p><b>Part II Metallomics in Environment and Nutrition 129</b></p> <p><b>6 Selenium and Selenium Species 131</b><br /><br />6.1 Speciation Analysis Especially of Tin and Selenium in Environmental Matrices 131<br /><i>Maria Ochsenkühn-Petropoulou and Fotios Tsopelas</i></p> <p>References 143</p> <p>6.2 Selenium Species Extraction and Speciation in Plants and Yeast 151<br /><i>Lena Ruzik, Katarzyna Bier?a, and Joanna Szpunar</i></p> <p>References 169</p> <p><b>7 Arsenic and As Species 173</b></p> <p>7.1 Arsenic Species in Marine Food 173<br /><i>María Carmen Barciela-Alonso and Pilar Bermejo-Barrera</i></p> <p>References 198</p> <p>7.2 Compounds with As–S Bonds: Analytical and Biogeochemical Reasons Why These Species have been Elusive in Biota and Environment 202<br /><i>Jörg Feldmann, Andrea Raab, Helle R. Hansen, Katharina Bluemlein, and Dirk Wallschläger</i></p> <p>References 218</p> <p>7.3 Arsenolipids: An overview of current analytical aspects 222<br /><i>Michael Stiboller, Ronald A. Glabonjat, Georg Raber, Kenneth B. Jensen, and Kevin A. Francesconi</i></p> <p>References 234</p> <p><b>8 Analytical Procedures for Speciation of Chromium, Aluminum, and Tin in Environmental and Biological Samples 237</b><br /><i>Radmila Milâcîc, Tea Zuliani, Janja Vidmar, and Janez Šcancar</i></p> <p>8.1 Speciation of Chromium 237</p> <p>8.2 Speciation of Aluminum 250</p> <p>8.3 Speciation of Tin 260</p> <p>References 275</p> <p><b>9 Mercury Toxicity and Speciation Analysis 285</b><br /><i>Eva M. Krupp, Zuzana Gajdosechova, Tanja Schwerdtle, and Hanna Lohren</i></p> <p>9.1 Mercury Toxicity 285</p> <p>9.2 Mercury Speciation Analysis 291</p> <p>References 298</p> <p><b>10 Environmental Speciation of Platinum Emissions from Chemotherapy 305</b><br /><i>Marianna Vitkova, Gunda Koellensperger, and Stephan Hann</i></p> <p>10.1 Introduction 305</p> <p>10.2 Elemental Analysis of Platinum 306</p> <p>10.3 Quantification Strategies 309</p> <p>10.4 Preparation of Samples for Total Platinum Analysis by ICP-MS 309</p> <p>10.5 Analysis of Platinum 310</p> <p>10.6 Speciation of Platinum Emissions from Chemotherapy 311</p> <p>10.7 Speciation Strategies for the Determination of CPC 312</p> <p>10.8 Selected Applications 312</p> <p>10.9 Conclusion 314</p> <p>References 315</p> <p><b>11 Nanoparticles in Environment and Health Effect 319</b><br /><i>Gaëtane Lespes</i></p> <p>11.1 Introduction 319</p> <p>11.2 Nanoparticle Overview 319</p> <p>11.3 Analytical Strategies 326</p> <p>11.4 Conclusion 334</p> <p>References 335</p> <p><b>Part III Metallomics in Medicine and Biology 339</b></p> <p><b>12 Metalloproteins 341</b><br /><i>Maria Montes-Bayón and Elisa Blanco-González</i></p> <p>12.1 General Introduction to Metalloprotein Analysis 341</p> <p>12.2 Sample Preparation Methodologies to Preserve Metal–Protein Interactions 342</p> <p>12.3 Analytical Strategies for Identification of Metalloproteins 344</p> <p>12.4 Quantitative Strategies for the Analysis of Metalloproteins 349</p> <p>References 355</p> <p><b>13 Biomedical and Pharmaceutical Applications 359</b><br /><br />13.1 Selenium and Selenoproteins in Human Health and Diseases 359<br /><i>Jordan Sonet, Anne-Laure Bulteau, and Laurent Chavatte</i></p> <p>Acknowledgments 370</p> <p>References 370</p> <p>13.2 Metal Species as Biomarkers for Medical Diagnosis: A Case Study of Alzheimer’s Disease 375<br /><i>Tamara García-Barrera, José Luis Gómez-Ariza, and Belén Callejón-Leblic</i></p> <p>References 385</p> <p>13.3 Vanadium Speciation as a Means in Drug Development and Monitoring for Diabetes 388<br /><i>Volker Nischwitz</i></p> <p>References 398</p> <p>13.4 Analysis of Pt- and Ru-Based Anticancer Drugs: New Developments 401<br /><i>Sarah Theiner, Luis Galvez, Gunda Koellensperger, and Bernhard K. Keppler</i></p> <p>References 416</p> <p>13.5 Silver Distribution in Skin duringWound Healing 420<br /><i>Marco Roman and Carlo Barbante</i></p> <p>References 436</p> <p>13.6 Neurodegeneration with Focus on Manganese and Iron Speciation 442<br /><i>Katharina Neth, Julia Bornhorst, and Bernhard Michalke</i></p> <p>References 457</p> <p>Index 463</p>

"This book covers a comprehensive and broad range of relevant topics in the field of Metallomics with an intended focus on analytical techniques and speciation methods, alone with the corresponding discussion on biometal(loid) sciences. Not only the scientists who are engaging in Metallomics study but also newcomers who want to do research on Metallomics will benefit from reading this book" <b>Qiuquan Wang on behalf of Springer, 31/07/2017</b>

Bernhard Michalke is leader of the research group "Elements and Element Speciation" and of the "Central Inorganic Analysis Division" as well as deputy director of the research unit "Analytical BioGeoChemistry" at the Helmholtz Center Munich - German Research Center for Environmental Health. <br> Since 1996 he has been lecturer at the Institute of Analytical Chemistry and Food Chemistry of the Technical University of Graz, Austria, where he received his habilitation in analytical chemistry in 1999. Since 1988, he is principal researcher at the Helmholtz Center Munich. <br> His reasearch interests encompass speciation projects related to environmental health, i.e. the exposure and chemical speciation of neuro-degenerative elements such as manganese and species related neuro-toxic effects in the central nervous system. He has published more than 170 peer reviewed articles and 10 book chapters. Since 1998, he has been co-organizer of several international conferences.

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