Details
Next Generation Sequencing in Cancer Research
Volume 1: Decoding the Cancer Genome|
CHF 212.50 |
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| Verlag: | Springer |
| Format: | |
| Veröffentl.: | 04.08.2013 |
| ISBN/EAN: | 9781461476450 |
| Sprache: | englisch |
| Anzahl Seiten: | 383 |
Dieses eBook enthält ein Wasserzeichen.
Beschreibungen
This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology.
<p>1. The evolution of high-throughput sequencing technologies: from Sanger to single molecule sequencing…..Chee-Seng Ku, Yudi Pawitan, Mengchu Wu, Dimitrios H. Roukos, David N. Cooper</p><p>2. Next generation sequencing in cancer epigenomics and potential clinical applications….Hong Kiat Ng, Dimitrios H. Roukos, Barry Iacopetta, Chee-Seng Ku</p><p>3. Next Generation Sequencing for Cancer Genomics…..Aarti N Desai and Abhay Jere</p><p>4. Genomic Landscape of Cancer Metastasis….Arvind Kumar Singla, Chandini Thirukkumaran<sup> </sup>and Wei Wu</p><p>5. Mapping the HIF transcription factor in cancer by ChIP-seq technology…..Johannes Schödel and David R. Mole</p><p>6. Application of next-generation sequencing to analysis of TGFβ/SMAD4 targets in ovarian cancer<b>…..</b>Russell Bonneville, Kenneth Nephew, and Victor X. Jin</p><p><b>7. </b>Targeted Sequencing Strategies in Cancer Research…..HoJoon Lee, Billy T. Lau and Hanlee P. Ji<b></b></p><p>8. Comprehensive genomic alterations in common cancer cell lines revealed by exome-sequencing…..Han Chang, Donald G. Jackson, Paul S. Kayne, Petra B. Ross-Macdonald, Rolf-Peter Ryseck, and Nathan O. Siemers</p><p>9. Application of next generation sequencing in RNA biomarker discovery in cancer research…..Stephen P. Fink, and Kishore Guda</p><p>10. Understanding the role of long non-coding RNAs in the cancer genome.....Wei Wu and Jennifer A. Chan</p><p>11. Identification of piRNAs in HeLa cells by massive parallel sequencing.....Yilu Lu and Yongxin Ma</p><p>12. microRNA expression in breast cancer revealed by deep sequencing technology.....Thalia A. Farazi, Carl S. Leonhardt, and Thomas Tuschl</p><p>13. RNA-seq in prostate cancer research.....ShanCheng Ren, Min Qu, Yinghao Sun</p><p>14. Next-generation sequencing for high-throughput RNA interference screens.....Toby M. Ward, Anna-Maria Jegg, and Elizabeth Iorns</p><p>15. Assessment of Mapping and SNP-detection Algorithms for Next Generation Sequencing Data for Cancer Genomics.....Weixin Wang, Feng Xu, Junwen Wang</p><p>16. Applications of very low coverage sequencing in cancer genomics copy number, virus detection and survival.....Henry M Wood</p><p>17. Tumor phylogenetics in the NGS era: Strategies, challenges and future prospects.....Ayshwarya Subramanian, Stanley Shackney and Russell Schwartz</p><p>18. Impact and challenges in assessing tumor purity by next-generation sequencing…..Xiaoping Su, Gabriel G. Malouf, and Francisco J. Esteva</p>
<p>Next Generation Sequencing (NGS) technology has placed important<br>milestones in the life science and changed the direction<br>in biomedical science inclucing cancer. Scientists around the<br>world are attempting to find the root cause of cancer and they<br>are looking for more direct and effective means to cure cancer.<br>This journey to conquer cancer is more optimistic now with<br>the unfolding of the cancer genome. This book focuses on the<br>application of various NGS in the frontier cancer genome research.<br>The 18 chapters in this volume have been written by<br>scientists with many outstanding contributions in their area<br>and the join effort has created comprehensive insightful view<br>on (1) Overview of next generation sequencing technology in<br>cancer genome research (2) Genome regulation and targeted<br>sequencing in cancer (3) RNA transcriptome (coding and<br>non-coding) in cancer genome (4)The challenges of computational<br>biology for cancer genome study.<br><br>This book is a state-of-the-art reference to all scientific researchers<br>and onologists who are interested in the understanding<br>of the cancer initiatome at whole genome scale and to those<br>are keen to translate the ‘base pairs to bedside’ for better management<br>of cancer patients in the era of personalized medicine.</p>
<p>Applies the Next Generation Sequencing (NGS) technology to practical and real cancer research projects?</p><p>Each chapter will briefly cover the outline for bioinformatic analysis</p><p>The primary audience are researchers and scientists in cancer biology, molecular biology, and other related areas in biomedical research</p>
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